#Borlak scannerz plus

Methods: NAFLD related HCC was induced by the combination of high fat and choline deficient diet with diethylnitrosamine (100 mg/L) for 16 weeks. At minus two weeks after the last DEN injection, the ROI of rats had significantly increased compared to the normal group, in a time-dependent manner These results suggest that FDG uptake serves as a good screening test to evaluate the feasibility of DEN-induced HCC.Īim: Evaluate the effect of sorafenib in a rat model of non-alcoholic fatty liver disease (NAFLD) related to hepatocellular carcinoma (HCC) by quantifying the correlation between changes in glucose metabolism on PET imaging and degree of tumor differentiation. The F-18-FDG uptake for the quantitative evaluation of HCC was done by measuring the region of interest (ROT). The serum levels of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphate (ALP) were significantly higher at zero weeks after the last DEN injection. The body weight of rats was maintained between 350 g and 370 g during 14 and 20 weeks, and the rats were euthanized at 35 days after the last DEN injection.

#Borlak scannerz plus

Also, an F-18-FDG PET scan and serum analysis were performed at minus 2, 0, plus 2, and plus 4 weeks after the last DEN injection. The weight and survival rate of rats were then measured. We recorded starting from 0 days or 0 weeks after the last DEN injection. Rats received weekly intraperitoneal injections of DEN for 16 weeks for induction of HCC. Here we investigated the feasibility of using F-18-FDG PET/CT in the diethylnitrosamine (DEN) mediated experimental hepatocellular carcinoma model. The uptake of 2-fluoro-2-deoxy-D-glucose (F-18-FDG) is widely used as a marker of increased glucose metabolism to monitor the progression of cancer with positron emission tomography (PET)/computed tomography (CT). However, the exact mechanism of the progression from cirrhosis to cancer remains unclear. Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC).